NOTCH1 Hijacks the Stress Response Machinery in T Acute Lymphoblastic Leukemia

Our study on how NOTCH1 directly regulates the expression of HSF1 and other key heat-shock proteins in T-ALL, supporting the survival of cancer cells, is now available online. Oncogenic NOTCH1 controls transcriptional activation of the heat shock response in T cell acute lymphoblastic #leukemia and uncovers potential biomarkers of sensitivity to HSP90 inhibition: — Nature Medicine (@NatureMedicine) July 26, 2018